University campus architecture is an important type of contemporary architecture, and due to the need for large-scale construction, existing studies have mainly focused on the overall planning of campuses and new buildings. With the concept of vertical “compound” and modern campus architecture design as the guide, this article proposes a structural system for the security assessment center of Beijing Jiaotong University’s Xiongan Campus as an example. For the effectiveness of the building design, this paper designs the corresponding evaluation index system, and introduces the entropy weight method to solve the index weights, and combines the fuzzy comprehensive evaluation to carry out the calculation and analysis. It also combines the quantile regression model to explore the influencing factors of the design of the safety evaluation center of Xiongan Campus of Beijiao University. The calculation results show that the comprehensive evaluation score of the design of the Xiongan Campus Security Assessment Center of Beijiao University is 4.006, which is at the level of good grade. And the geographical environment, campus planning, site conditions and faculty and student needs all have a positive influence on the construction of the Security Assessment Center of Xiongan Campus of NJTU at the 1% level. Therefore, it is necessary to build an overall planning and design framework from a global perspective, and pay full attention to the quality of the built environment, so as to ensure that the architectural design of the Center of Xiongan Campus of Beijiao University is more in line with the needs of the campus buildings.