Taking Zhenxiong County as the research area and Zhenxiong County in Yunnan Province as the study area, this study systematically evaluated the susceptibility of landslide disasters using the susceptibility index method. By collecting and analyzing multi-source data such as geology, topography, meteorology, and human activities in the research area, a landslide susceptibility evaluation index system was constructed based on the determination of key factors affecting landslide susceptibility. ArcGIS technology was used to extract relevant evaluation factors and determine the weights of each index. Based on this, the susceptibility index method was used to quantitatively evaluate the susceptibility of landslide disasters in Zhenxiong County. The study area was divided into extremely high susceptibility areas, high susceptibility areas, medium susceptibility areas, low susceptibility areas, and non susceptibility areas. The results showed that the high susceptibility areas of landslide disasters in Zhenxiong County exhibited a clear band like distribution. In response to the above results, this article proposes corresponding prevention and control measures, aiming to provide scientific basis for preventing and reducing the risk of landslide disasters and ensuring the safety of people’s lives and property.