Dormitory as an important activity place of campus life, the quality of its indoor thermal environment, and the diversity of its functions are directly related to students’ learning efficiency as well as physiological and psychological health. In this paper, starting from the demand for indoor thermal comfort in student dormitories, we studied human thermal comfort, as well as the way and principle of heat exchange between the human body and the outside world, and put forward six parameters affecting the thermal comfort of the human body. A design strategy based on passive retrofit thermal storage roofing, as well as spatial layout co-optimisation is conceived to jointly enhance the indoor thermal comfort of dormitories, and to improve the psychological health and academic performance of university students. A real-life laboratory experiment was conducted to explore the effects of the thermal environment of the dormitory on college students’ mental health under the optimal design from the perspective of built environment science. Quantitative and objective evaluations were conducted to assess the effects of indoor thermal environment on students’ academic performance and academic performance. It was found that under the optimised accommodation environment, the thermo-neutral temperature of university students was 22.78℃. Both academic performance and academic achievement reached their maximum values at 24℃, which significantly improved the academic performance of college students. The maximum value of the psychological health index of university students was measured to be 3.05, and the minimum value was -1.60, which were within the limit values of the indoor thermal comfort model of the dormitory, indicating that the psychological health level of students was improved in the optimised accommodation environment.