Under the background of contemporary rapid urban development and people’s growing spiritual needs, residential space not only assumes the function of living, but also carries the role of psychological comfort and emotional regulation. Painting art, as an important component of soft furnishings, is becoming an important means to enhance the psychological comfort of the occupants. This study explores the influence of the application of painting art in different residential space styles on the psychological comfort of the occupants, constructs an evaluation index system with the dimensions of social, recreational and psychotherapeutic, and determines the weights of each index through the hierarchical analysis method (AHP). After carrying out empirical analysis on three types of residential styles (Chinese classical, European classical, and modern styles), it was found that the painting art of the modern style had the highest score on psychological comfort, 80.9; the Chinese classical style was 70.1, and the European classical style was 69.6. The critical role of the 14 evaluation indexes in psychological comfort enhancement was further verified through the analysis of necessity and sufficiency conditions. The study concludes that modern style painting art is more advantageous in promoting emotional regulation, spatial perception and active activities, which can significantly improve the psychological comfort and humanistic care level of residential space.