With the rapid development of the Internet and e-commerce technology, the traditional real estate transaction mode is experiencing unprecedented changes. This study explores the impact of e-commerce development on the innovation of online transaction mode in real estate market through fuzzy hierarchical analysis and multiple regression analysis. It is found that the development of e-commerce significantly promotes the innovation of real estate transaction mode, and this effect shows a significant positive effect at different innovation levels. Specifically, for every 1% increase in the level of e-commerce development, the level of real estate transaction model innovation increases by 0.122%. In addition, factors such as the level of economic development, per capita income and industrial structure also play a positive role in promoting real estate transaction model innovation. By analyzing the data of a region from 2015-2024, the results show that the online transaction mode innovation in the real estate market has shown a rising trend year by year, indicating that the extensive application of e-commerce in this field has had a far-reaching impact. The conclusion further emphasizes the importance of the integration of e-commerce and the real estate market, and provides recommendations for real estate companies to strengthen e-commerce.