This paper takes the listed high-tech manufacturing enterprises in Shanghai and Shenzhen A-shares from 2019 to 2024 as the research object, extracts the relevant panel data, and conducts descriptive statistics and correlation analysis on them. The panel data are utilized to establish the effect model based on the panel data, and the direct effect test is conducted. Through polynomial regression and response surface analysis, the synergistic mechanism between related variables is discussed. The empirical study shows that the digital transformation of enterprises and the development level of big data processing methods and cloud computing significantly promote enterprise innovation and development. And all of them showed a significant (P<0.001) positive effect in terms of effect test. The effects of synergistic interaction terms on both innovation quantity and innovation quality were significantly (P < 0.01 or P < 0.05) positive. Therefore, this synergistic mechanism is fully considered to promote the development of digital transformation innovation in enterprises.