The comprehensive energy distribution network (DN for short here) integrates multiple energy sources, which is the main direction for the development of the power system DN. To solve the problems of low efficiency in collaborative allocation between power sources, power grids, and loads in traditional integrated energy DN coordination operation models, difficulty in meeting power quality requirements, and susceptibility to interference from external environmental factors, this article analyzed the traditional integrated energy DN coordination operation model. This paper summarized the key technologies of the distribution scheme between the coordinated operation power supply, power grid and load, and optimized the coordinated operation structure of the integrated energy grid based on the distribution demand and particle swarm optimization algorithm. This can improve the intelligence level of the decision-making scheme for coordinated operation of source network load. Finally, this article conducted comparative experiments to verify the performance improvement of optimizing the comprehensive energy DN. From the results of the comparative experiment, it can be seen that compared to traditional comprehensive energy DN, the optimized comprehensive energy DN has shorter decision-making time, better equipment management ability, and stronger risk response performance. In the application comparative experiment, the evaluation index of risk response performance increased by 18%. The optimization of the comprehensive energy DN in this article has played an important role in the development process of the DN, and it is one of the excellent solutions to promote large-scale energy allocation and consumption. Its coordinated operation between power sources, power grids, and loads is also more efficient and smooth, fully tapping the potential of various energy sources, and it has more objective prospects in technological updates and iterations.