The integrated development of transportation and tourism is a strategic choice to cope with the diversified needs of tourists, and also an important way to transform and upgrade the tourism industry in the new development period. In this paper, 14 prefecture-level cities in Guangxi are taken as research samples. Based on the comprehensive development level of transportation industry and tourism industry in Guangxi, a comprehensive evaluation index system of transportation industry and tourism industry in Guangxi is established. By collecting and analyzing panel data from 2010 to 2022, Coupled coordination degree analysis and exploratory spatial data analysis are used to evaluate and analyze the development level of transportation and tourism integration in Guangxi, measure the comprehensive level of transportation and tourism industry in Guangxi and their integrated development status, and analyze the spatio-temporal evolution characteristics and influencing factors of transportation and tourism integration in Guangxi based on the integrated development status of prefecture-level cities.