In this study, a flexible interconnection topology design method based on intelligent algorithm-driven design is proposed for the flexibility and stability needs of low-voltage distribution networks in new energy highpenetration scenarios, and new energy access strategies are optimized by combining with the honeycomb active distribution network (HADN) structure. By improving the Davignan equivalent impedance voltage drop model and introducing the relative electrical distance matrix, the fast calculation of the static voltage stability index (SVSI) of the distribution network is realized, which reduces the computational complexity of topology optimization. The designed HADN topology supports active/reactive power optimization by realizing dynamic energy mutualization and cooperative protection among microgrid clusters through smart power exchange base stations (SPIES). Simulation experiments show that the proposed strategy has good adaptability under complex operating conditions, with PV power prediction accuracies of 93.14% day-ahead and 98.86% intraday, and unregulatable load prediction accuracies of 86.18% (day-ahead) and 96.34% (intraday), respectively. In the steady state operation, each distributed power source (DG) stabilizes rapidly, of which the combined photovoltaic battery system, photovoltaic power generation system, fuel cell and wind power generation system reach the steady state within 1s, 0.5s, 0.3s and 4s, respectively.