Laser cutting technology has the advantages of high precision, high speed, good kerf quality, etc., and has a broad application prospect in the processing of railroad ties. Existing railroad tie processing equipment exists in the lack of flexibility, cutting quality fluctuations and other problems. In view of the quality control problems of railroad tie laser cutting processing, the research designed a high-power railroad tie laser cutting system based on PLC and industrial robot, and use fuzzy PID control strategy for intelligent control. The system integrates PLC technology, industrial robot technology, height-adjustment detection technology and laser cutting technology, and the influence of laser power, cutting speed, laser frequency and auxiliary gas pressure on cutting quality is studied by Box-Behnken experimental design method. The experiment was verified by LC-F1000-L fiber laser cutting machine and 3.2mm thick Q235 mild steel plate. The results show that the laser power has the most significant effect on the amount of slag hanging and roughness, and the compound correlation coefficients of the response surface fitting accuracy of the amount of slag hanging and roughness reach 0.9613 and 0.9609, respectively; after the application of the fuzzy PID controller, the response time of the Y-direction displacement is 0.4s, which is shortened by 1.86s compared with that of the traditional PID controller, while the response time of the X-direction displacement is 0.5s, which is reduced by 1.3s compared with that of the traditional PID controller. The fuzzy PID controller is better than the traditional PID controller in terms of position response characteristics and corner response characteristics. This study provides theoretical basis and practical guidance for the design of highprecision railroad tie laser cutting system, which is of great value for the improvement of railroad tie processing accuracy and production efficiency.