China’s economy has shifted from the stage of high-speed growth to the stage of high-quality development, and the problem of unbalanced regional economic development has become increasingly prominent. Fiscal policy, as an important means of national macroeconomic regulation and control, plays a key role in promoting the highquality development of regional economy. This paper constructs a regional economic high-quality development evaluation system based on the information entropy model, and uses the spatial econometric model to test the influence mechanism of fiscal policy regulation on regional economic high-quality development. The study selected the data of Chinese provinces from 2017 to 2024, measured the level of high-quality development of regional economy through the entropy weight method, and applied the fixed effect model and spatial Durbin model to analyze the influence effect of fiscal policy regulation. The results show that: fiscal policy regulation has a significant role in promoting regional economic high-quality development, and the coefficient of fiscal policy regulation in the fixedeffect model is 0.478; regional heterogeneity analysis shows that the coefficient of fiscal policy regulation in the eastern region is the highest at 0.489, in the western region it is 0.101, and it is not significant in the central and northeastern regions; the spatial effect decomposition shows that fiscal policy regulation has a direct effect of 0.668, and a direct effect of 0.668, and a spatial effect decomposition shows that fiscal policy regulation has a The direct effect is 0.668, the indirect effect is 0.346, and the total effect is 1.045. The study proposes the optimization of the path of fiscal policy regulation from the developmental to the livelihood, from the demand side to the supply side, and from the administrative to the market side, which provides the theoretical support and policy inspiration for the promotion of high-quality development of regional economy.
