In recent years, the cultural and tourism integration model has played an important role in practice all over China. Based on the integrated development of culture and tourism in Guangxi, this paper constructs the evaluation index system and calculates the weights by using the subjective and objective combination assignment method. Then based on fuzzy mathematical theory, the fuzzy comprehensive evaluation method is used to obtain the evaluation of the comprehensive development level of Guangxi’s culture and tourism, and the coupling coordination degree is utilized to explore the integrated development of the two. The average development levels of culture and tourism in Guangxi during the study period are 0.513 and 0.555 respectively, and the extreme values of the development levels are 0.41 and 0.47 respectively, and the tourism industry has a better level and speed of development, but with greater volatility. The overall development of cultural and tourism integration in Guangxi is in the state of mild dislocation and on the verge of dislocation, and the coupling coordination degree is all less than 0.5, and the cultural and tourism integration shows a gradual upward development trend in zigzagging, but there is still a large space for upward movement. Except for 2017-2018 and 2021-2022, the cultural and tourism integration in the rest of the years of the study period is in the state of cultural lag. Countermeasures are proposed to strengthen the construction of talent team, expand the whole industry chain of culture and tourism and strengthen the cultural excavation and inheritance in order to promote the sustainable development of culture and tourism integration in Guangxi.