With the accelerating process of globalization, the overseas dissemination of Chinese culture has ushered in new opportunities and challenges. This paper takes TCM acupuncture in Chinese culture as an example to evaluate and analyze the effect and acceptance of overseas communication of Chinese culture. The entropy weightTOPSIS method is used to obtain the weights of the indicators of Chinese culture dissemination effect, and quantitative evaluation analysis is carried out. With the help of Qualitative Comparative Analysis (QCA) method, the consistency and coverage monitoring analysis of Chinese culture’s overseas communication effect continues. The results of the ranking of the evaluation indicators of the effect of Chinese culture dissemination overseas based on the weights are: cognitive indicators (54.03%) > behavioral indicators (31.1%) > attitudinal indicators (14.87%). And in the similarity analysis, the communication effect score of the nine content modules of Chinese medicine and acupuncture averaged 0.11, the overall overseas communication effect is not satisfactory, and it is still necessary to further improve the overseas communication effect of Chinese culture.