With HV/EHV DC transmission gradually becoming the main mode of regional power grid interconnection, the problem of multiregional protection coordination of AC/DC hybrid power systems has become an important issue that needs to be concerned and solved. Based on the relevant theoretical knowledge and simulation platform, the AC/DC hybrid power system is designed, and then the multi-area protection coordination problem of the system is converted into a nonlinear planning problem by combining the concept and characteristics of distributed computing. Based on the objective function, constraints, and optimized particle swarm algorithm, to design the multi-area protection coordination scheme of AC/DC hybrid power system, and the scheme is empirically analyzed. The optimal protection coordination time of the AC/DC hybrid power system with the introduction of distributed generation equipment is 2.531s, i.e., after the optimization of the algorithm in this paper, the protection coordination performance of the system is further optimized, so that the system can better serve the electricity customers.