Elderly caregivers are a key group in the development of long-term care business, and their burnout problem is becoming more and more prominent. As the two main work arrangement methods, 24/7 system and shift system have different impacts on caregiver burnout. Based on the support vector machine model, this study compares and analyzes the differences in burnout between 24/7 caregivers and shift system caregivers. A random whole cluster sampling method was used to select 185 caregivers from 18 elderly care facilities in 6 districts of a city as the study subjects, and data were collected through a general information questionnaire and the Masler Burnout Inventory (MBI-GS), and analyzed by using the SPSS22.0 software and the support vector machine model. The results showed that the round-the-clock group (24-hour workday) was more likely to experience high levels of burnout than the shift-based group (12-hour workday) (OR=2.34, 95% CI: 1.63-3.49, p<0.001); The longer the working years, the more serious the burnout, and the burnout scores of caregivers who had worked for more than 3 years (50.73±13.12) were significantly higher than those of caregivers who had worked for less than 1 year (38.96±16.51); the prediction model based on the influencing factors had the highest accuracy, correctly predicting 150 cases; the number of hours of work per day (importance score of 80.19) and work stress (importance score of 70.40 ) were the main factors affecting caregiver burnout. The study suggests that rationalization of work system design can effectively reduce caregiver burnout, and it is recommended that senior care institutions adopt scientific work system arrangements and conduct regular burnout assessment and intervention.