Emotional design has always been an important topic in indoor spaces, significantly impacting people’s living experiences and quality of life. This paper first uses the PAD model to construct a mood space and a state space model to construct an emotional space, quantitatively describing the relationship between personality, mood, and emotion. Subsequently, based on the OCC and PAD emotional models, emotional calculations are performed on the various dimensions of “place attachment,” analyzing emotional characteristics through people’s satisfaction with the spatial environment of buildings. Finally, a multiple regression model is established to explore the subjective comfort scores of interior design under a spatial emotional expression model based on multi-dimensional data calculation and analysis. In simulated experiments comparing the comfort of interior design spaces, comfort scores were mostly above 4 points, indicating that, overall, people have a positive evaluation of the comfort of interior design spaces.