As the Internet technology develops rapidly, wireless communication and VR interaction emerge as the times require and continue to get into people’s lives. As the endless penetration of wireless communication and Virtual Reality (VR) interaction into various fields, education has become one of them. Among them, college education is a vital component in the education domain. The mixed English teaching of network technology and VR technology is a new idea. There are many problems in the current traditional college English teaching, which makes its method unable to fit in the level of contemporary economic and social development. Based on VR interaction and wireless communication technology, this paper innovatively studied the mixed college English teaching design, which combined traditional English teaching with VR technology. Through analyzing of blended teaching of college English, students’ professional skills and comprehensive quality could be effectively improved. The results showed that the blended college English teaching was more conducive to improving the teaching consequence and promoting students to command expertise and their comprehensive competency could be enhanced. The first test results showed that 1444.5 was the total score of the control class, while the total score of the experimental class was 1469.5. Moreover, through statistical analysis, the average score of the experimental class was 1.3 points higher. Compared with the first month, the English scores of the two groups had little difference. However, after calculation, the average score of the experimental class was 1.6 higher. In the third exam, the students’ grades in the English test of the two classes were studied, and the average scores were further improved. Based on the analysis of the survey statistics, the paper found that the mixed English teaching model constructed in this paper had certain practical application value and promotion value. Through the analysis of English teaching, this paper expounded the method of combining wireless communication technology with virtual reality technology, which carved a brand-new method for the development of mixed English teaching mode in the future.