This paper systematically describes the sustainable development design of urban residential buildings and summarizes the basic principles and design concepts. Under the guidance of evaluation index system, 18 evaluation indexes are selected to form a coupling index system of Tibetan, Qiang and Yi culture and residential building development. Comprehensive entropy weight method and coupling coordination method form the coupling model of Tibetan, Qiang and Yi culture and residential building, in addition to determining the data sources, and using the model to assess the cultural heritage of Tibetan, Qiang and Yi characteristics and the level of development of urban residential building. 2013, the coupling coordination between the two is located in the range of 0.1~0.2, which indicates that the coupling level is located in the extremely dysfunctional recession, and at the same time, reveals the difficulties faced by the two, and in order to improve their development, proposes In order to improve their development, two targeted coupling development strategies are proposed to promote the synergistic development of the two.